Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report.

ABSTRACT:

Background

Various antiepileptic drugs can potentially cause psychiatric side effects in patients with epilepsy, but the precise mechanism of these actions remains unknown. In recent years, the common polymorphism C677T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has attracted attention for its role in the onset of psychiatric diseases. MTHFR and several vitamins (as cofactors) are crucial for remethylation of homocysteine via folate and homocysteine metabolism. We report a case of a Japanese patient who presented with reversible schizophrenia-like symptoms during antiepileptic drug therapy.

Case presentation

Our patient had frontal lobe epilepsy and had been treated with several antiepileptic drugs since the age of 13 years. He developed auditory hallucinat

SUBMITTER: Shimura M 

PROVIDER: S-EPMC6689870 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature