Transsynaptic Fish-lips signaling prevents misconnections between nonsynaptic partner olfactory neurons.

ABSTRACT: Our understanding of the mechanisms of neural circuit assembly is far from complete. Identification of wiring molecules with novel mechanisms of action will provide insights into how complex and heterogeneous neural circuits assemble during development. In the Drosophila olfactory system, 50 classes of olfactory receptor neurons (ORNs) make precise synaptic connections with 50 classes of partner projection neurons (PNs). Here, we performed an RNA interference screen for cell surface molecules and identified the leucine-rich repeat-containing transmembrane protein known as Fish-lips (Fili) as a novel wiring molecule in the assembly of the Drosophila olfactory circuit. Fili contributes to the precise axon and dendrite targeting of a small subset of ORN and PN classes, respectiv

SUBMITTER: Xie Q 

PROVIDER: S-EPMC6689933 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature