Insights into the origin of the high energy-conversion efficiency of F₁-ATPase.

ABSTRACT: Our understanding of the rotary-coupling mechanism of F₁-ATPase has been greatly enhanced in the last decade by advances in X-ray crystallography, single-molecular imaging, and theoretical models. Recently, Volkán-Kacsó and Marcus [S. Volkán-Kacsó, R. A. Marcus, Proc. Natl. Acad. Sci. U.S.A. 112, 14230 (2015)] presented an insightful thermodynamic model based on the Marcus reaction theory coupled with an elastic structural deformation term to explain the observed γ-rotation angle dependence of the adenosine triphosphate (ATP)/adenosine diphosphate (ADP) exchange rates of F₁-ATPase. Although the model is successful in correlating single-molecule data, it is not in agreement with the available theoretical results. We describe a revision of the model, which leads

SUBMITTER: Nam K 

PROVIDER: S-EPMC6690014 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature