Time-of-flight secondary ion mass spectrometry three-dimensional imaging of surface modifications in poly(caprolactone) scaffold pores.

ABSTRACT: Scaffolds composed of synthetic polymers such as poly(caprolactone) (PCL) are widely used for the support and repair of tissues in biomedicine. Pores are common features in scaffolds as they facilitate cell penetration. Various surface modifications can be performed to promote key biological responses to these scaffolds. However, verifying the chemistry of these materials post surface modification is problematic due to the combination of three-dimensional (3D) topography and surface sensitivity. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is commonly used to correlate surface chemistry with cell response. In this study, 3D imaging mass spectrometry analysis of surface modified synthetic polymer scaffolds is demonstrated using PCL porous scaffold, a pore filling polymer sample

SUBMITTER: Taylor MJ 

PROVIDER: S-EPMC6690353 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature