Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials.

ABSTRACT:

Introduction

This study estimated the minimal clinically important difference (MCID) for Mini Mental State Examination, Clinical Dementia Rating Scale sum of boxes, and Functional Activities Questionnaire across the Alzheimer's disease (AD) spectrum.

Methods

Retrospective analysis of the National Alzheimer's Coordinating Center Uniform Data Set (9/2005-9/2016) and MCID for clinical outcomes were estimated using anchor-based (clinician's assessment of meaningful decline) and distribution-based (1/2 baseline standard deviation) approaches, stratified by severity of cognitive impairment.

Results

On average, a 1-3 point decrease in Mini Mental State Examination, 1-2 point increase in Clinical Dementia Scale sum of boxes, and 3-5 point increase in Functional Activities Que

SUBMITTER: Andrews JS 

PROVIDER: S-EPMC6690415 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature