Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis.
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ABSTRACT: Aim
The aim of this study was to determine the immunologic effects and safety of oral anti-CD3 in patients with ulcerative colitis (UC).Methods
An open-label pilot study of orally delivered anti-CD3 was performed in patients with moderate-to-severe UC. The primary end points were changes in immunologic parameters and evaluation for safety.Results
Six subjects received oral OKT3. Biologic effects of oral anti-CD3 included significantly increased proliferation in response to anti-CD3 and anti-inflammatory gene expression profile in peripheral blood mononuclear cells. No serious treatment-related adverse events occurred.Conclusion
Orally delivered anti-CD3 resulted in immunologic changes in patients with UC.
SUBMITTER: Boden EK
PROVIDER: S-EPMC6690423 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis.
Boden Elisa K EK Canavan James B JB Moran Christopher J CJ McCann Katelyn K Dunn William A WA Farraye Francis A FA Ananthakrishnan Ashwin N AN Yajnik Vijay V Gandhi Roopali R Nguyen Deanna D DD Bhan Atul K AK Weiner Howard L HL Korzenik Joshua R JR Snapper Scott B SB
Crohn's & colitis 360 20190607 2
<h4>Aim</h4>The aim of this study was to determine the immunologic effects and safety of oral anti-CD3 in patients with ulcerative colitis (UC).<h4>Methods</h4>An open-label pilot study of orally delivered anti-CD3 was performed in patients with moderate-to-severe UC. The primary end points were changes in immunologic parameters and evaluation for safety.<h4>Results</h4>Six subjects received oral OKT3. Biologic effects of oral anti-CD3 included significantly increased proliferation in response t ...[more]
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