Crystal structure analysis of the biologically active drug mol-ecule riluzole and riluzolium chloride.

ABSTRACT: This study is an investigation into the crystal structure of the biologically active drug mol-ecule riluzole [RZ, 6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-2-amine], C₈H₅F₃N₂OS, and its derivative, the riluzolium chloride salt [RZHCl, 2-amino-6-(tri-fluoro-meth-oxy)-1,3-benzo-thia-zol-3-ium chloride], C₈H₆F₃N₂OS⁺·Cl^-. In spite of repeated efforts to crystallize the drug, its crystal structure has not been reported to date, hence the current study provides a method for obtaining crystals of both riluzole and its corresponding salt, riluzolium hydro-chloride. The salt was obtained by grinding HCl with the drug and crystallizing the obtained solid from di-chloro-methane. The crystals

SUBMITTER: Mondal PK 

PROVIDER: S-EPMC6690469 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature