Chemoselective, Postpolymerization Modification of Bioactive, Degradable Polymers.

ABSTRACT: Degradable polymers promote sustainability, mitigate environmental impact, and facilitate biological applications. Tailoring degradable polymers is challenging because installing functional group-rich side chains is difficult when the backbone itself is susceptible to degradation. A convenient means of side chain installation is through postpolymerization modification (PPM). In functionalizing polyoxazinones, a class of degradable polymers generated by the ring-opening metathesis polymerization (ROMP), we predictably found PPM challenging. Even the versatile azide-alkyne cycloaddition click reaction was ineffective. To solve this problem, we screened PPM reactions whose efficiencies could be assessed using photochemistry (excimer formation). The mildest, pH-neutral process was functionaliz

SUBMITTER: Fishman JM 

PROVIDER: S-EPMC6690479 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature