Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.

ABSTRACT:

Objective

To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.

Methods

A Delphi survey including 99 items was circulated among international experts for 3 rounds.

Results

Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.

Conclusion

This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

SUBMITTER: Aydin SZ 

PROVIDER: S-EPMC6690481 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature