Homeostatic controllers compensating for growth and perturbations.

ABSTRACT: Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and synthetic biology community to recognize and design control circuits which can oppose the diluting effects of cell growth. In this paper we describe the performance of selected negative feedback controllers in response to different applied growth laws and time dependent outflow perturbations of a controlled variable. The approach taken here is based on deterministic mass action kinetics assuming that cell content is instantaneously mixed. All controllers behave ideal in the sense that they for step-wise perturbations in volume and a controlled compound A are able to driv

SUBMITTER: Ruoff P 

PROVIDER: S-EPMC6690524 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature