Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization.

ABSTRACT: In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype or to an anti-inflammatory M2 phenotype, as well as existing on a spectrum between these two extremes. Dysfunction of this phenotypic switch can result in a population imbalance that leads to chronic wounds or disease due to unresolved inflammation. Therapeutic interventions that target macrophages have therefore been proposed and implemented in diseases that feature chronic inflammation such as diabetes mellitus and atherosclerosis. We have developed a model for the sequential influx of immune cells in the peritoneal cavity in response to a bacterial stimulus that includes macrophage polarization, with the simplifying assumption that macrophages can be classified as M1 or M2. With this model, we were

SUBMITTER: Torres M 

PROVIDER: S-EPMC6690555 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature