Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans.

ABSTRACT: HLA class I and KIR sequences were determined for Dogon, Fulani, and Baka populations of western Africa, Mbuti of central Africa, and Datooga, Iraqw, and Hadza of eastern Africa. Study of 162 individuals identified 134 HLA class I alleles (41 HLA-A, 60 HLA-B, and 33 HLA-C). Common to all populations are three HLA-C alleles (C1⁺C*07:01, C1⁺C*07:02, and C2⁺C*06:02) but no HLA-A or -B Unexpectedly, no novel HLA class I was identified in these previously unstudied and anthropologically distinctive populations. In contrast, of 227 KIR detected, 22 are present in all seven populations and 28 are novel. A high diversity of HLA A-C-B haplotypes was observed. In

SUBMITTER: Nemat-Gorgani N 

PROVIDER: S-EPMC6690726 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature