Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.

ABSTRACT:

Purpose

Diabetes leads to progressive complications such as diabetic retinopathy, which is the leading cause of blindness within the working-age population worldwide. Interleukin (IL)-17A is a cytokine that promotes and progresses diabetes. The objective of this study was to determine the role of IL-17A in retinal capillary degeneration, and to identify the mechanism that induces retinal endothelial cell death. These are clinically meaningful abnormalities that characterize early-stage non-proliferative diabetic retinopathy.

Methods

Retinal capillary degeneration was examined in vivo using the streptozotocin (STZ) diabetes murine model. Diabetic-hyperglycemia was sustained for an 8-month period in wild type (C57BL/6) and IL-17A^-/- mice to elucidate the role of IL-

SUBMITTER: Lindstrom SI 

PROVIDER: S-EPMC6690768 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature