Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells.

ABSTRACT: Paeonol (Pae), a phenolic acid compound isolated from the Moutan Cortex, was previously demonstrated to exert multiple anticancer effects. The rational control of autophagy has been considered a potential treatment strategy for epithelial ovarian cancer. However, whether Pae induces autophagy and the relationship between its antitumour activities and autophagy in epithelial ovarian cancer are still unclear. In this study, we found that Pae induced not only antiproliferation activity and apoptosis but also autophagy, and complete autophagic flux was observed in A2780 and SKOV3 cells. In addition, combination treatment with Pae and an autophagy inhibitor (3-methyladenine and hydroxychloroquine) showed significant synergetic effects on inhibiting cell viability and promoting apoptosis in vitr

SUBMITTER: Gao L 

PROVIDER: S-EPMC6690917 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature