Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation.

ABSTRACT: Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation. Donor T cell addback can accelerate immune reconstitution but the therapeutic window between graft-vs.-host disease and protective immunity is very narrow in the haploidentical transplant setting. Hence, strategies to improve the safety and efficacy of adoptive T cell transfer are particularly relevant in this setting. Adoptive T cell transfer strategies in haploidentical transplantation include the use of antigen-specific T cells, allodepletion and alloanergy induction, immune modulation by the co-infusion of regulatory cell populations, and the use of safety switch gene-modified T cells. Whilst c

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6691120 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature