Adiponectin Decreases Gastric Smooth Muscle Cell Excitability in Mice.

ABSTRACT: Some adipokines known to regulate food intake at a central level can also affect gastrointestinal motor responses. These are recognized to be peripheral signals able to influence feeding behavior as well. In this view, it has been recently observed that adiponectin (ADPN), which seems to have a role in sending satiety signals at the central nervous system level, actually affects the mechanical responses in gastric strips from mice. However, at present, there are no data in the literature about the electrophysiological effects of ADPN on gastric smooth muscle. To this aim, we achieved experiments on smooth muscle cells (SMCs) of gastric fundus to find out a possible action on SMC excitability and on membrane phenomena leading to the mechanical response. Experiments were made inserting a mic

SUBMITTER: Idrizaj E 

PROVIDER: S-EPMC6691180 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature