Identification of differentially expressed genes in hip cartilage with femoral head necrosis, based on genome‑wide expression profiles.

ABSTRACT: Necrosis of the femoral head (NFH), a severe orthopedic disease in adults, involves the collapse of the femoral head. The pathophysiological mechanisms underlying NFH are yet to be fully investigated. The aim of the present study was to identify potentially important genes and signaling pathways involved in NFH and investigate their molecular mechanisms. Gene expression profiles of patients with NFH and healthy controls were compared using the Gene Expression Omnibus (GEO) database repository of the National Center of Biotechnology Information. GSE74089 from the GEO database included 4 patients with NFH and 4 healthy individuals. A total of 1,191 differentially expressed genes (DEGs) were identified between the patients with NFH and controls, including 743 upregulated and 448 downregulated

SUBMITTER: Li WC 

PROVIDER: S-EPMC6691263 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature