Medial prefrontal cortex exacerbates gastric dysfunction of rats upon restraint water‑immersion stress.

ABSTRACT: Restraint water‑immersion stress (RWIS) can induce a gastric mucosal lesions within a few hours. The medial prefrontal cortex (mPFC) is involved in the RWIS process. The present study investigated the modulatory effects and molecular mechanisms of the mPFC on gastric function under an RWIS state. Male Wistar rats were divided into four groups; namely, the control, RWIS 4 h (RWIS for 4 h only), sham‑operated and bilateral‑lesioned (bilateral‑lesioned mPFC) groups. The gastric erosion index (EI) and gastric motility (GM) were determined, and the proteomic profiles of the mPFC were assessed by isobaric tags for relative and absolute quantitation (iTRAQ) coupled with two‑dimensional liquid chromatography and tandem mass spectrometry. Additionally, iTRAQ results were verified by western blot an

SUBMITTER: Zhao DQ 

PROVIDER: S-EPMC6691265 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature