DNA hypermethylation of aurora kinase A in hepatitis C virus‑positive hepatocellular carcinoma.

ABSTRACT: Changes in the methylation levels of tumor suppressor genes or proto‑oncogenes are involved in the pathogenesis of hepatitis C virus (HCV) infection‑induced hepatocellular carcinoma (HCC). The aim of the present study was to identify novel aberrantly methylated differentially expressed genes by integrating mRNA expression profile (GSE19665 and GSE62232) and methylation profile (GSE60753) microarrays downloaded from the Gene Expression Omnibus database. Functional enrichment analysis of screened genes was performed using the DAVID software and BinGO database. Protein‑protein interaction (PPI) networks were constructed using the STRING database, followed by module analysis with MCODE software. The transcriptional and translational expression levels of crucial genes were confirmed using The Can

SUBMITTER: Ma Z 

PROVIDER: S-EPMC6691273 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature