The Endless Saga of Monocyte Diversity.

ABSTRACT: Cancer immunotherapy relies on either restoring or activating the function of adaptive immune cells, mainly CD8⁺ T lymphocytes. Despite impressive clinical success, cancer immunotherapy remains ineffective in many patients due to the establishment of tumor resistance, largely dependent on the nature of tumor microenvironment. There are several cellular and molecular mechanisms at play, and the goal is to identify those that are clinically significant. Among the hematopoietic-derived cells, monocytes are endowed with high plasticity, responsible for their pro- and anti-tumoral function. Indeed, monocytes are involved in several cancer-associated processes such as immune-tolerance, metastatic spread, neoangiogenesis, and chemotherapy resistance; on the other hand, by presenting ca

SUBMITTER: Cane S 

PROVIDER: S-EPMC6691342 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature