Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats.

ABSTRACT: We have characterized a lean type 2 diabetic rat model by gestational low protein programming. We aimed to identify if the regulation of hepatic glucose production (HGP) via gluconeogenesis and glycogenolysis is affected and if there are any sex differences. Fasting (6-7 months old) type 2 diabetic rats received ²H₂O followed by a primed constant rate infusion of [6,6-²H₂] glucose. Blood samples were drawn during steady states after 4 h of fasting and following a euglycemic hyperinsulinemic clamp. HGP and the fraction of glucose derived from gluconeogenesis under fasting and euglycemic states were measured from steady state glucose enrichments after the infusion of [6,6-²H₂]glucose and ²H₂O tracers. Gly

SUBMITTER: Blesson CS 

PROVIDER: S-EPMC6691354 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature