Sex modulates the ApoE ε4 effect on brain tau deposition measured by ¹⁸F-AV-1451 PET in individuals with mild cognitive impairment.

ABSTRACT: The strongest genetic risk factor for Alzheimer's disease (AD) is the Apolipoprotein E type 4 allele (ApoE ε4). The interaction between sex and ApoE ε4 carrier status on AD risk remains an area of intense investigation. We hypothesized that sex modulates the relationship between ApoE ε4 carrier status and brain tau deposition (a quantitative endophenotype in AD) in individuals with mild cognitive impairment (MCI). Methods: Preprocessed ¹⁸F-AV-1451 tau and ¹⁸F-AV-45 amyloid PET images, T1-weighted structural magnetic resonance imaging (MRI) scans, demographic information, and cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau (p-tau) measurements from 108 MCI subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were include

SUBMITTER: Liu M 

PROVIDER: S-EPMC6691387 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature