Analysis of Vibrio cholerae genomes identifies new type VI secretion system gene clusters.

ABSTRACT:

Background

Like many bacteria, Vibrio cholerae deploys a harpoon-like type VI secretion system (T6SS) to compete against other microbes in environmental and host settings. The T6SS punctures adjacent cells and delivers toxic effector proteins that are harmless to bacteria carrying cognate immunity factors. Only four effector/immunity pairs encoded on one large and three auxiliary gene clusters have been characterized from largely clonal, patient-derived strains of V. cholerae.

Results

We sequence two dozen V. cholerae strain genomes from diverse sources and develop a novel and adaptable bioinformatics tool based on hidden Markov models. We identify two new T6SS auxiliary gene clusters and describe Aux 5 here. Four Aux 5 loci are present in the host strain, each with an atypi

SUBMITTER: Crisan CV 

PROVIDER: S-EPMC6691524 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature