Development of a prediction model for breast cancer based on the national cancer registry in Taiwan.

ABSTRACT:

Background

This study aimed to develop a prognostic model to predict the breast cancer-specific survival and overall survival for breast cancer patients in Asia and to demonstrate a significant difference in clinical outcomes between Asian and non-Asian patients.

Methods

We developed our prognostic models by applying a multivariate Cox proportional hazards model to Taiwan Cancer Registry (TCR) data. A data-splitting strategy was used for internal validation, and a multivariable fractional polynomial approach was adopted for prognostic continuous variables. Subjects who were Asian, black, or white in the US-based Surveillance, Epidemiology, and End Results (SEER) database were analyzed for external validation. Model discrimination and calibration were evaluated in both intern

SUBMITTER: Huang CC 

PROVIDER: S-EPMC6691540 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature