Identification and Validation of Tumor Stromal Immunotype in Patients With Hepatocellular Carcinoma.

ABSTRACT: Background: The immune landscape of hepatocellular carcinoma (HCC) is heterogeneous. This study aims to develop the immune type which could improve predictive value of HCC survival. Methods: A total of 208 HCC patients in the testing cohort, 112 patients in the validation cohort and 365 HCC patients in the TCGA database were included in this study. Immune features were assessed by immunohistochemical staining or CIBERSORT method. We constructed prognostic classifiers by LASSO COX analyses in the TCGA cohort, which identified five features out of the 22 types of immune cells. Results: The formulas based on the immunohistochemical staining are as follows: IS_OS = 0.648^* Macrophage_stromal + 0.444^*Neutrophils_stromal + 0

SUBMITTER: Li W 

PROVIDER: S-EPMC6691778 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature