Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta.

ABSTRACT: Betaine derivatives are considered major ingredients of shampoos and are commonly used as antistatic and viscosity-increasing agents. Several studies have also suggested that betaine derivatives can be used as antimicrobial agents. However, the antifungal activity and mechanism of action of betaine derivatives have not yet been fully understood. In this study, we investigated the antifungal activity of six betaine derivatives against Malassezia restricta, which is the most frequently isolated fungus from the human skin and is implicated in the development of dandruff. We found that, among the six betaine derivatives, lauryl betaine showed the most potent antifungal activity. The mechanism of action of lauryl betaine was studied mainly using another phylogenetically close model funga

SUBMITTER: Do E 

PROVIDER: S-EPMC6691833 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature