Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model.

ABSTRACT: Neuroprotection has proven clinically unsuccessful in subarachnoid hemorrhage. We believe that this is because the major component in the early damage pathway, the vascular wall, has not been given the necessary focus. U0126 is a potent inhibitor of vascular phenotypical changes, exemplified by functional endothelin B (ET_B) receptor upregulation. The current study aimed to determine the optimal dose of U0126 ex vivo and test the toxicology of this dose in vivo. To find the optimal dose and test a suitable in vivo delivery system, we applied an ex vivo model of blood flow cessation and investigated functional ET_B receptor upregulation (using a specific agonist) as the primary endpoint. The secondary endpoint was depolarization-induced contra

SUBMITTER: Christensen ST 

PROVIDER: S-EPMC6691891 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature