Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

ABSTRACT: Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here, we provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung-resident γδ T cells. Germ-free or antibiotic-treated mice were significantly protected from lung cancer development induced by Kras mutation and p53 loss. Mechanistically, commensal bacteria stimulated Myd88-dependent IL-1β and IL-23 production from myeloid cells, inducing proliferation and activation of Vγ6⁺Vδ1⁺ γδ T cell

SUBMITTER: Jin C 

PROVIDER: S-EPMC6691977 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature