Contrasting DNA methylation responses of inbred fish lines to different rearing environments.

ABSTRACT: Epigenetic mechanisms generate plastic phenotypes that can become locally adapted across environments. Disentangling genomic from epigenomic variation is challenging in sexual species due to genetic variation among individuals, but it is easier in self-fertilizing species. We analysed DNA methylation patterns of two highly inbred strains of a naturally self-fertilizing fish reared in two contrasting environments to investigate the obligatory (genotype-dependent), facilitated (partially depend on the genotype) or pure (genotype-independent) nature of the epigenetic variation. We found higher methylation differentiation between genotypes than between environments. Most methylation differences between environments common to both strains followed a pattern where the two genotypes (inbred lines

SUBMITTER: Berbel-Filho WM 

PROVIDER: S-EPMC6691983 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature