Energetic substrate availability regulates synchronous activity in an excitatory neural network.

ABSTRACT: Neural networks are required to meet significant metabolic demands associated with performing sophisticated computational tasks in the brain. The necessity for efficient transmission of information imposes stringent constraints on the metabolic pathways that can be used for energy generation at the synapse, and thus low availability of energetic substrates can reduce the efficacy of synaptic function. Here we study the effects of energetic substrate availability on global neural network behavior and find that glucose alone can sustain excitatory neurotransmission required to generate high-frequency synchronous bursting that emerges in culture. In contrast, obligatory oxidative energetic substrates such as lactate and pyruvate are unable to substitute for glucose, indicating that processes

SUBMITTER: Tourigny DS 

PROVIDER: S-EPMC6692003 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature