Cost-effectiveness analysis of universal varicella vaccination in Turkey using a dynamic transmission model.

ABSTRACT:

Background

In 2013, Turkey introduced one-dose universal varicella vaccination (UVV) at 12 months of age. Inclusion of a second dose is being considered.

Methods

We developed a dynamic transmission model to evaluate three vaccination strategies: single dose at 12 months (1D) or second dose at either 18 months (2D-short) or 6 years of age (2D-long). Costs and utilization were age-stratified and separated into inpatient and outpatient costs for varicella and herpes zoster (HZ). We ran the model including and excluding HZ-related costs and impact of exogenous boosting.

Results

Five years post-introduction of UVV (1D), the projected varicella incidence rate decreases from 1,674 cases pre-vaccine to 80 cases/100,000 person-years. By 25 years, varicella incidence equilibrat

SUBMITTER: Wolfson LJ 

PROVIDER: S-EPMC6692038 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature