Spatial dynamics within and between brain functional domains: A hierarchical approach to study time-varying brain function.

ABSTRACT: The analysis of time-varying activity and connectivity patterns (i.e., the chronnectome) using resting-state magnetic resonance imaging has become an important part of ongoing neuroscience discussions. The majority of previous work has focused on variations of temporal coupling among fixed spatial nodes or transition of the dominant activity/connectivity pattern over time. Here, we introduce an approach to capture spatial dynamics within functional domains (FDs), as well as temporal dynamics within and between FDs. The approach models the brain as a hierarchical functional architecture with different levels of granularity, where lower levels have higher functional homogeneity and less dynamic behavior and higher levels have less homogeneity and more dynamic behavior. First, a high-order sp

SUBMITTER: Iraji A 

PROVIDER: S-EPMC6692083 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature