Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice.

ABSTRACT: Exposure to stress increases the risk of developing mood disorders. While a subset of individuals displays vulnerability to stress, others remain resilient, but the molecular basis for these behavioral differences is not well understood. Using a model of chronic social defeat stress, we identified region-specific differences in myelination between mice that displayed social avoidance behavior ('susceptible') and those who escaped the deleterious effect to stress ('resilient'). Myelin protein content in the nucleus accumbens was reduced in all mice exposed to stress, whereas decreased myelin thickness and internodal length were detected only in the medial prefrontal cortex (mPFC) of susceptible mice, with fewer mature oligodendrocytes and decreased heterochromatic histone marks. Focal demye

SUBMITTER: Bonnefil V 

PROVIDER: S-EPMC6692108 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature