CT radiomics associations with genotype and stromal content in pancreatic ductal adenocarcinoma.

ABSTRACT: PURPOSE:The aim of this study was to investigate the relationship between CT imaging phenotypes and genetic and biological characteristics in pancreatic ductal adenocarcinoma (PDAC). METHODS:In this retrospective study, consecutive patients between April 2015 and June 2016 who underwent PDAC resection were included if previously consented to a targeted sequencing protocol. Mutation status of known PDAC driver genes (KRAS, TP53, CDKN2A, and SMAD4) in the primary tumor was determined by targeted DNA sequencing and results were validated by immunohistochemistry (IHC). Radiomic features of the tumor were extracted from the preoperative CT scan and used to predict genotype and stromal content. RESULTS:The cohort for analysis consisted of 35 patients. Genomic and IHC analysis revealed alteration

SUBMITTER: Attiyeh MA 

PROVIDER: S-EPMC6692205 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature