Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.

ABSTRACT: Glioblastoma multiforme alters healthy tissue vasculature by inducing angiogenesis and vascular remodeling. To fully comprehend the structural and functional properties of the resulting vascular network, it needs to be studied collectively by considering both geometric and topological properties. Utilizing Single Plane Illumination Microscopy (SPIM), the detailed capillary structure in entire healthy and tumor-bearing mouse brains could be resolved in three dimensions. At the scale of the smallest capillaries, the entire vascular systems of bulk U87- and GL261-glioblastoma xenografts, their respective cores, and healthy brain hemispheres were modeled as complex networks and quantified with fundamental topological measures. All individual vessel segments were further quantified geometricall

SUBMITTER: Hahn A 

PROVIDER: S-EPMC6692362 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature