A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.

ABSTRACT: Mitochondria play a central and multifunctional role in the progression of tumorigenesis. Although many recent studies have demonstrated correlations between mitochondrial function and genetic makeup or originating tissue, it remains unclear why some cancers are more susceptible to mitocans (anticancer drugs that target mitochondrial function to mediate part or all of their effect). Moreover, fundamental questions of efficacy and mechanism of action in various tumor types stubbornly remain. Here we demonstrate that cancer type is a significant predictor of tumor response to mitocan treatment, and that acute myeloid leukemias (AML) show an increased sensitivity to these drugs. We determined that AML cells display particular defects in mitochondrial metabolism that underlie their sensitivity

SUBMITTER: Panina SB 

PROVIDER: S-EPMC6692368 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature