Associations between common respiratory viruses and invasive group A streptococcal infection: A time-series analysis.

ABSTRACT:

Background

Invasive infections by group A Streptococcus (iGAS, Streptococcus pyogenes) have a winter seasonality which largely coincides with the season for influenza and other respiratory viruses. Influenza superinfections with GAS have been described to occur regularly and to show a severe clinical picture with high mortality. We aimed to study the extent to which influenza A and B viruses (IAV and IBV), respiratory syncytial virus (RSV) and rhinovirus circulation contribute to iGAS incidence and severity.

Methods

Time-series regression models were built to explore the temporal associations between weekly laboratory counts of IAV, IBV, RSV and rhinovirus as independent variables and weekly counts of GAS disease notifications or laboratory GAS cultures as dependent variable

SUBMITTER: de Gier B 

PROVIDER: S-EPMC6692538 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature