Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells.

ABSTRACT: Cancer cells have the unique ability to overcome natural defense mechanisms, undergo unchecked proliferation and evade apoptosis. While chemotherapeutic drugs address this, they are plagued by a long list of side effects and have a poor success rate. This has spurred researchers to identify safer bioactive compounds that possess chemopreventive and therapeutic properties. A wide range of experimental as well as epidemiological data encourage the use of dietary agents to impede or delay different stages of cancer. In the present study, we have examined the anti-ancer property of ubiquitous phytochemical quercetin by using cell viability assay, flow cytometry, nuclear morphology, colony formation, scratch wound assay, DNA fragmentation and comet assay. Further, qPCR analysis of various genes

SUBMITTER: Kedhari Sundaram M 

PROVIDER: S-EPMC6692570 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature