The plant product quinic acid activates Ca²⁺ -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells.

ABSTRACT:

Background and purpose

Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta-cell functions, which contribute to the control of metabolic health by lowering blood glucose. Strategies targeting beta-cell signal transduction are a new approach for diabetes treatment. This study investigated the efficacy of QA to stimulate beta-cell function by targeting the basic molecular machinery of metabolism-secretion coupling.

Experimental approach

We measured bioenergetic parameters and insulin exocytosis in a model of insulin-secreting beta-cells (INS-1E), together with Ca²⁺ homeostasis, using genetically encoded sensors, targeted to different subcellul

SUBMITTER: Heikkila E 

PROVIDER: S-EPMC6692587 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature