Joint effects of fatty acid desaturase 1 polymorphisms and dietary polyunsaturated fatty acid intake on circulating fatty acid proportions.

ABSTRACT:

Background

Polyunsaturated fatty acids (PUFAs) are associated with a lower risk of multiple diseases. Fatty acid desaturase 1 gene (FADS1) polymorphisms and dietary PUFA intake are both established determinants of circulating PUFA proportions.

Objective

We explored the joint effects of FADS1 polymorphisms and dietary PUFA intake on circulating PUFA proportions.

Design

We studied 2288 participants from a nested case-control study of coronary artery disease among participants who provided blood samples in the Nurses' Health Study and the Health Professionals Follow-Up Study. Dietary PUFA intake was obtained from semiquantitative food-frequency questionnaires. FADS1 rs174546 was genotyped by using the Affymetrix 6.0 platform, and circulating PUFA proportions were measure

SUBMITTER: Juan J 

PROVIDER: S-EPMC6692647 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature