Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia.

ABSTRACT:

Importance

The association between late-life blood pressure (BP) and cognition may depend on the presence and chronicity of past hypertension. Late-life declines in blood pressure following prolonged hypertension may be associated with poor cognitive outcomes.

Objective

To examine the association of midlife to late-life BP patterns with subsequent dementia, mild cognitive impairment, and cognitive decline.

Design, setting, and participants

The Atherosclerosis Risk in Communities prospective population-based cohort study enrolled 4761 participants during midlife (visit 1, 1987-1989) and followed-up over 6 visits through 2016-2017 (visit 6). BP was examined over 24 years at 5 in-person visits between visits 1 and 5 (2011-2013). During visits 5 and 6, participants underw

SUBMITTER: Walker KA 

PROVIDER: S-EPMC6692677 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature