Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions.

ABSTRACT:

Importance

The effect of intensive blood pressure lowering on brain health remains uncertain.

Objective

To evaluate the association of intensive blood pressure treatment with cerebral white matter lesion and brain volumes.

Design, setting, and participants

A substudy of a multicenter randomized clinical trial of hypertensive adults 50 years or older without a history of diabetes or stroke at 27 sites in the United States. Randomization began on November 8, 2010. The overall trial was stopped early because of benefit for its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20, 2015. Brain magnetic resonance imaging (MRI) was performed on a subset of participants at baseline (n = 670) and at 4 years of follow-up (n = 449); final f

SUBMITTER: SPRINT MIND Investigators for the SPRINT Research Group 

PROVIDER: S-EPMC6692679 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature