Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults.

ABSTRACT:

Importance

Depressive symptoms are prevalent among older adults and may be early manifestations of Alzheimer disease (AD) before onset of mild cognitive impairment. However, it remains unclear whether worsening depressive symptoms in the presence of AD pathology are associated with cognitive decline in older adults.

Objective

To determine the longitudinal association between depressive symptoms, cognition, and cortical amyloid in community-dwelling older adults.

Design, setting, and participants

Participants from the Harvard Aging Brain Study, a cohort study, underwent annual assessments of depression and cognition and baseline cortical amyloid measurement (mean, 4.42 years; range, 2-7 years). Data collection was from September 2010 to August 2017 in a convenience sam

SUBMITTER: Gatchel JR 

PROVIDER: S-EPMC6692684 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature