Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo.

ABSTRACT:

Importance

In multiple sclerosis (MS), chronic active lesions, which previously could only be detected at autopsy, can now be identified on susceptibility-based magnetic resonance imaging (MRI) in vivo as non-gadolinium-enhancing lesions with paramagnetic rims. Pathologically, they feature smoldering inflammatory demyelination at the edge, remyelination failure, and axonal degeneration. To our knowledge, the prospect of long-term in vivo monitoring makes it possible for the first time to determine their contribution to disability and value as a treatment target.

Objective

To assess whether rim lesions are associated with patient disability and long-term lesion outcomes.

Design, setting, participants

We performed 3 studies at the National Institutes of Health Clinical

SUBMITTER: Absinta M 

PROVIDER: S-EPMC6692692 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature