Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio.

ABSTRACT:

Aims

The instantaneous wave-free ratio (iFR) and whole-cycle Pd/Pa investigate coronary physiology during non-hyperaemic conditions. To test for unique physiologic properties of the wave-free period when making resting coronary pressure measurements, we compared post hoc a diastolic pressure ratio (dPR) and Pd/Pa against iFR for numerical similarity and test/retest repeatability.

Methods and results

Eight hundred and ninety-three lesions from 833 subjects were included from the VERIFY 2 and CONTRAST studies. Diastolic pressure ratio and a linear transform of Pd/Pa were compared against iFR for diagnostic performance. Mean difference between dPR and iFR [Δ = -0.006 ± 0.011, r2 = 0.993, area under receiver operating characteristic (ROC) curve (AUC) = 0.997] mirrored the differ

SUBMITTER: Johnson NP 

PROVIDER: S-EPMC6692701 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature