Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.

ABSTRACT:

Context

Plasma betaine correlates with insulin sensitivity in humans. Betaine supplementation improves metabolic effects in mice fed a high-fat diet.

Objective

To assess metabolic effects of oral betaine in obese participants with prediabetes.

Design

A 12-week, parallel arm, randomized, double-masked, placebo-controlled trial.

Setting

University-affiliated hospital.

Participants and interventions

Persons with obesity and prediabetes (N = 27) were randomly assigned to receive betaine 3300 mg orally twice daily for 10 days, then 4950 mg twice daily for 12 weeks, or placebo.

Main outcome measures

Changes from baseline in insulin sensitivity, glycemia, hepatic fat, and endothelial function.

Results

There was a 16.5-fold increase in plasma dimet

SUBMITTER: Grizales AM 

PROVIDER: S-EPMC6692715 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature