Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations.

ABSTRACT: A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca²⁺-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (K_Ca²⁺ = 2.4 × 10⁵ M^-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel net

SUBMITTER: Sanchez-Fernandez MJ 

PROVIDER: S-EPMC6692821 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature