Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice.

ABSTRACT: Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization; however, it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized. Behavioral tests revealed that mice with endometriosis were more depressed, anxious and sensitive to pain compared to sham controls. Microarray analyses confirmed by qPCR identified differential gene expression in several regions of brain in mice with endometriosis. In these mice

SUBMITTER: Li T 

PROVIDER: S-EPMC6692844 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature