Temporal transcriptomic analysis of metabolic genes in maternal organs and placenta during murine pregnancy.

ABSTRACT: Maternal pregnancy adaptation is crucial for fetal development and long-term health. Complex interactions occur between maternal digestive and excretory systems as they interface with the developing fetus through the placenta, and transcriptomic regulation in these organs throughout pregnancy is poorly understood. Our objective is to characterize transcriptomic changes across gestation in maternal organs and placenta. Gene expression was quantified in the kidney, liver, and small intestine harvested from nonpregnant and pregnant FVB mice at four time points and placenta at three time points (N = 5/time point) using Affymetrix Mouse Gene 1.0 ST arrays. In maternal organs, we identified 476 genes in the liver, 207 genes in the kidney, and 27 genes in the small intestine that were differentia

SUBMITTER: Paquette A 

PROVIDER: S-EPMC6692859 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature