Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

ABSTRACT: Proper regulation of energy metabolism requires neurons in the central nervous system to respond dynamically to signals that reflect the body's energy reserve, and one such signal is leptin. Agouti-related protein (AgRP) is a hypothalamic neuropeptide that is markedly upregulated in leptin deficiency, a condition that is associated with severe obesity, diabetes, and hepatic steatosis. Because deleting AgRP in mice does not alter energy balance, we sought to determine whether AgRP plays an indispensable role in regulating energy and hepatic lipid metabolism in the sensitized background of leptin deficiency. We generated male mice that are deficient for both leptin and AgRP [double-knockout (DKO)]. DKO mice and ob/ob littermates had similar body weights, food intake, energy expenditure, and

SUBMITTER: Maier MT 

PROVIDER: S-EPMC6692877 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature